Amygdala kindling increased fear-response, but did not impair spatial memory in rats.
作者： Sakari A. Nieminen , Jouni Sirviö , Kalevi Teittinen , Asla Pitkänen , Mauno M. Airaksinen
DOI: 10.1016/0031-9384(92)90125-L
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摘要: Abstract The behavioral effects of amygdala kindling, a model experimental epilepsy in rats, are reported. animals were stimulated twice day until stage 5 (generalized clonic) seizures obtained three times. Two weeks later the performance amygdalakindled and sham-operated rats was tested open-field test, on elevated plus maze, bridges, Morris water maze. results show that kindling decreased exploratory other motor activity had anxiogenic plus-maze, boldness but negligible affect spatial memory task. These suggest affects normal fear reaction response is known to be mediated through amygdaloid pathways.
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