DUBs, the regulation of cell identity and disease.

摘要: The post-translational modification of proteins with ubiquitin represents a complex signalling system that co-ordinates essential cellular functions, including proteolysis, DNA repair, receptor and cell communication. DUBs (deubiquitinases), the enzymes disassemble chains remove from proteins, are central to this system. Reflecting complexity versatility signalling, DUB activity is controlled in multiple ways. Although several lines evidence indicate aberrant function may promote human disease, underlying molecular mechanisms often unclear. Notwithstanding, considerable interest as potential drug targets has emerged over past years. future success DUB-based therapy development will require connecting basic science enzymology discovery. In present review, we discuss new insights into regulation their links focusing on role regulators identity differentiation, emerging targets.