Vascular endothelial growth factors and receptors in colorectal cancer: Implications for anti-angiogenic therapy

摘要: There are conflicting associations between growth factor expression and clinicopathological variables in colorectal cancer. This study aimed to define the of members VEGF family receptor, VEGFR2, primary metastatic sites cancer their relationship potential. Thirty cancers, 12 lymph node metastases 9 liver were immunostained for VEGF-A, VEGF-C, VEGF-D VEGFR2. VEGFR2 was expressed by endothelial cells malignant epithelium. VEGF-C co-expressed same territory correlated throughout tumour nodes, but not metastases. Their at invasive edge with nodes. The benefit anti-VEGF antibodies might be increased directing additional therapies against or kinase receptors target redundancy system. A component therapeutic due a direct anti-tumour effect as well an anti-angiogenic effect.