Growth hormone-releasing hormone and interleukin-1 in sleep regulation.

摘要: Growth hormone-releasing hormone (GHRH) and interleukin-1 (IL-1) are putative endogenous sleep-promoting substances. Evidence is reviewed showing that, 1) GHRH IL-1 promote non-rapid eye movement sleep (NREMS); 2) if their production enhanced, enhanced; 3) they inhibited using either specific antibodies or peptide antagonists, reduced. Both in the brain both also indirectly linked to sleep/wake cycles by various other evidence, e.g., growth release plasma levels vary phase with cycles. Finally, actions directly each other; IL-1-induced mediated via GHRH. The evidence strongly implicates as key components humoral regulation. Humoral theories of regulation complementary neural theories; mechanisms affect undoubtedly continuously interact regulate