Diurnal variation of TNFα in the rat brain
作者： Rachael A. Floyd , James M. Krueger
DOI: 10.1097/00001756-199703030-00020
关键词:
摘要: Tumor necrosis factor-alpha (TNF alpha) is thought to play a physiological role in the brain. These studies were performed determine whether diurnal rhythm of TNF alpha exist rat Samples collected from hippocampus, hypothalamus, cerebral cortex, cerebellum, pons and midbrain at light onset 6 h intervals thereafter over day. A bioassay was used measure each area. highest hippocampus cortex. Levels about 10-fold greater than minimal night-time levels. Changes activity other brain areas also evident, but smaller. results support hypothesis that has roles
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