Modulation of the transcripts for tumor necrosis factor-α and its receptorsin vivo
作者： Brigitte Critico , Georges E. Grau
关键词:
摘要: We investigated the effects of a single bacterial lipopolysaccharide (LPS) injection in vivo on gene expression tumor necrosis factor-alpha (TNF) and its receptors: TNF receptor type I (TNF-R 55 kDa or TNF-R1) II 75 TNF-R2) various tissues white blood cells. While mRNA rapidly accumulated most tissues, TNF-R1 TNF-R2 levels were found to be differentially regulated lung, spleen, lymph nodes In cases, TNF-R did not parallel levels. These observations indicate that both types capable modulating host response LPS, only by shedding their extracellular domains, but also strict regulation expression.
sci-hub.se 参考文章(23)
D. G. Remick, K. Z. Guo, B. Irwin, G. N. Davatelis, T. R. Ulich, Endotoxin-induced cytokine gene expression in vivo. II. Regulation of tumor necrosis factor and interleukin-1 alpha/beta expression and suppression. American Journal of Pathology. ,vol. 137, pp. 1173- 1185 ,(1990)
A Ferrante, P Seckinger, B Hauptmann, J M Dayer, Inhibition of tumour necrosis factor alpha (TNF-alpha)-induced neutrophil respiratory burst by a TNF inhibitor. Immunology. ,vol. 72, pp. 440- 442 ,(1991)
A H Ding, E Sanchez, S Srimal, C F Nathan, Macrophages rapidly internalize their tumor necrosis factor receptors in response to bacterial lipopolysaccharide. Journal of Biological Chemistry. ,vol. 264, pp. 3924- 3929 ,(1989) , 10.1016/S0021-9258(19)84941-4
F. Porteu, M. Brockhaus, D. Wallach, H. Engelmann, C.F. Nathan, Human neutrophil elastase releases a ligand-binding fragment from the 75-kDa tumor necrosis factor (TNF) receptor. Comparison with the proteolytic activity responsible for shedding of TNF receptors from stimulated neutrophils. Journal of Biological Chemistry. ,vol. 266, pp. 18846- 18853 ,(1991) , 10.1016/S0021-9258(18)55141-3
R Winzen, O Kemper, Y Nophar, D Wallach, C Brakebusch, H Holtmann, K Resch, H Engelmann, Selective decrease in cell surface expression and mRNA level of the 55-kDa tumor necrosis factor receptor during differentiation of HL-60 cells into macrophage-like but not granulocyte-like cells. Journal of Immunology. ,vol. 148, pp. 3454- 3460 ,(1992)
B J van Lenten, A M Fogelman, Lipopolysaccharide-induced inhibition of scavenger receptor expression in human monocyte-macrophages is mediated through tumor necrosis factor-alpha. Journal of Immunology. ,vol. 148, pp. 112- 116 ,(1992)
Bruce Beutler, TNF in Pathophysiology: Biosynthetic Regulation Journal of Investigative Dermatology. ,vol. 95, pp. S81- S84 ,(1990) , 10.1111/1523-1747.EP12874797
A H Ding, F Porteu, E Sanchez, C F Nathan, Downregulation of tumor necrosis factor receptors on macrophages and endothelial cells by microtubule depolymerizing agents. Journal of Experimental Medicine. ,vol. 171, pp. 715- 727 ,(1990) , 10.1084/JEM.171.3.715
U Trefzer, M Brockhaus, H Lötscher, F Parlow, A Budnik, M Grewe, H Christoph, A Kapp, E Schöpf, T A Luger, The 55-kD tumor necrosis factor receptor on human keratinocytes is regulated by tumor necrosis factor-alpha and by ultraviolet B radiation. Journal of Clinical Investigation. ,vol. 92, pp. 462- 470 ,(1993) , 10.1172/JCI116589
B Beutler, I. Milsark, A. Cerami, Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin Science. ,vol. 229, pp. 869- 871 ,(1985) , 10.1126/SCIENCE.3895437