Susceptibility of Klebsiella pneumoniae Isolates from Intra-Abdominal Infections and Molecular Characterization of Ertapenem-Resistant Isolates

摘要: A total of 2,841 clinical isolates Klebsiella pneumoniae from intra-abdominal infections worldwide were collected in the Study for Monitoring Antimicrobial Resistance Trends (SMART) during 2008 and 2009. Overall, 22.4% had extended-spectrum β-lactamases (ESBLs). The most active antibiotics among 11 tested imipenem, amikacin, ertapenem, though even these, like all other comparators, less consistently against ESBL-positive than ESBL-negative isolates. Globally, 6.5% ertapenem resistant based on June 2010 breakpoints published by Clinical Laboratory Standards Institute, with MICs ≥1 μg/ml. Molecular characterization 43 ≥4 μg/ml showed that they variously produced CTX-M or SHV ESBLs combined altered impermeability and/or KPC (n = 28), OXA-48 3), VIM 1) carbapenemases. Further monitoring susceptibility molecular ertapenem-resistant are needed.