Invited review--neuroimaging response assessment criteria for brain tumors in veterinary patients.

摘要: The evaluation of therapeutic response using cross-sectional imaging techniques, particularly gadolinium-enhanced MRI, is an integral part the clinical management brain tumors in veterinary patients. Spontaneous canine are increasingly recognized and utilized as a translational model for study human tumors. However, no standardized neuroimaging assessment criteria have been formulated use trials. Previous studies found that pathophysiologic features inherent to surrounding complicate solid (RECIST) system. Objectives this review describe strengths limitations published imaging-based tumor propose system widely used Macdonald neuro-oncology (RANO) reviewed described how they can be applied Discussion points will include current challenges associated with interpretation responses such pseudophenomena treatment-induced necrosis, advancements perfusion imaging, positron emission tomography, magnetic resonance spectroscopy shown promise differentiating progression from therapy-induced changes. Finally, although objective endpoints MR survival estimates likely continue comprise foundations outcome measures trials, we order provide more relevant metric patients, composite systems should validated combine criteria.