Glioblastoma multiforme of the elderly: the prognostic effect of resection on survival.

摘要: According to recent developments the best treatment options for glioblastoma (GBM) consist in maximum safe resection and additional adjuvant with radiotherapy (RT) alkylating chemotherapy (CHX). These have been evaluated populations a median age of approximately 58 years. We therefore addressed issue whether elderly patients (>65years) could also benefit from cytoreductive surgery (CS) using chemotherapy. One-hundred three suffering newly diagnosed, primary supratentorial multiforme >65 years (median 70.8 years) were identified our single-center glioma database (2002–2007) retrospectively divided into group A (n = 31) treated alone (biopsy, BY, n 21, CS 10), B 37) plus radiation (BY 18, 19), C 35) surgery, RT CHX 4, 31). Progression-free survival (PFS) overall (OAS) determined each correlated age, Karnofsky performance score (KPS), extent (biopsy (BY), partial (PR), complete (CR)). Progression was defined according Macdonald criteria. For all PFS OAS 3.2 months 5.1 (m) respectively. groups A/B/C 1.8/3.2/6.4 m (P 0.000) 2.2/4.4/15.0 0.000), Median 74.4/70.6/68.5 KPS 60/70/80. Age (<75, ≥75) inversely (5.8/2.5 m, P 0.01). (<70, ≥70) 2.4/6.5 0.000). Extent (BY, PR, or CR) (2.1/3.4/6.4 0,000) OS (2.2/7.0/13.9 0,000), Our study shows that GBM can procedures microsurgery, therapy, Treatment are obviously affected by age. The most impressive outcome predictor this population microsurgical To conclude, should not be per se excluded intensive procedures.