Thyroid Hormone Regulation of Mammalian Reproductive Development and the Potential Impact of Endocrine-Disrupting Chemicals

摘要: Thyroid hormones are essential for growth and development of all vertebrate organisms. A growing literature reveals that thyroid centrally important in the reproductive tissues. In males, predominant target is developing testis with aberrant Sertoli Leydig cell accompanying testicular dysfunction. Hypothyroidism has also been associated precocious puberty a distinct subpopulation adolescent girls. The hypothalamic–pituitary–thyroid axis numerous endocrine-disrupting chemicals. Intriguingly, many these chemicals perturb function mammalian We now review key detailing role provide an analysis evidence linking thyroidal disruption by polychlorinated biphenyl, polybrominated diphenyl ether, phthalate, triclosan, bisphenol exposure, maldevelopment systems.