HPV infection and p53 inactivation in pterygium
作者： Yi-Yu Tsai , Chi-Chung Chang , Chun-Chi Chiang , Kun-Tu Yeh , Pei-Liang Chen
DOI:
关键词: Carcinogenesis 、 Cancer research 、 Gene 、 HPV infection 、 Pathogenesis 、 Gene silencing 、 Virology 、 Biology 、 Tumor suppressor gene 、 Pterygium 、 Immunohistochemistry
摘要: Purpose Our recent report indicated that tumor suppressor gene (p53) mutations and protein aberrant expression were detected in pterygium. Inactivation of p53 by Human papillomavirus (HPV) 16/18 E6 plays a crucial role cervical tumorigenesis. In this study, we further speculate inactivation may be linked with HPV infection pterygium pathogenesis. To investigate the involvement pterygium, association between 16 or 18 infection, oncoprotein, was analyzed study.
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