The human papillomavirus E6 protein and its contribution to malignant progression.

作者: Fiamma Mantovani , Lawrence Banks

DOI: 10.1038/SJ.ONC.1204869

关键词: OncogeneVirologyHuman papillomavirusVirusCellular proteinsMalignant progressionMalignancyE6 proteinBiologyMalignant Conversion

摘要: … In this review we shall address the functions of E6 which appear most relevant for cell … aspects of E6 function. Prior to this we will review the studies which define the high-risk HPV E6 as …

参考文章(172)
P. Hawley-Nelson, K.H. Vousden, N.L. Hubbert, D.R. Lowy, J.T. Schiller, HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes. The EMBO Journal. ,vol. 8, pp. 3905- 3910 ,(1989) , 10.1002/J.1460-2075.1989.TB08570.X
J.M. Huibregtse, M. Scheffner, P.M. Howley, A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18. The EMBO Journal. ,vol. 10, pp. 4129- 4135 ,(1991) , 10.1002/J.1460-2075.1991.TB04990.X
A. J. Bannister, T. Kouzarides, CBP-induced stimulation of c-Fos activity is abrogated by E1A. The EMBO Journal. ,vol. 14, pp. 4758- 4762 ,(1995) , 10.1002/J.1460-2075.1995.TB00157.X
M.S. Lechner, D.H. Mack, A.B. Finicle, T. Crook, K.H. Vousden, L.A. Laimins, Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription. The EMBO Journal. ,vol. 11, pp. 3045- 3052 ,(1992) , 10.1002/J.1460-2075.1992.TB05375.X
E.J. Androphy, N.L. Hubbert, J.T. Schiller, D.R. Lowy, Identification of the HPV-16 E6 protein from transformed mouse cells and human cervical carcinoma cell lines. The EMBO Journal. ,vol. 6, pp. 989- 992 ,(1987) , 10.1002/J.1460-2075.1987.TB04849.X
A Burny, C Desaintes, S Hallez, P Van Alphen, Transcriptional activation of several heterologous promoters by the E6 protein of human papillomavirus type 16. Journal of Virology. ,vol. 66, pp. 325- 333 ,(1992) , 10.1128/JVI.66.1.325-333.1992
David Bilder, Norbert Perrimon, Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature. ,vol. 403, pp. 676- 680 ,(2000) , 10.1038/35001108