Dose adjustment and supportive care before and during treatment

作者: Antonella Brunello , Elena Loaldi , Lodovico Balducci

DOI: 10.1016/J.CTRV.2009.04.009

关键词: MEDLINEAnemiaPhysical therapyMedicineComorbidityRandomized controlled trialMedical prescriptionIntensive care medicineAdverse effectConcomitantCancer

摘要: Though elderly patients represent a majority of cancer patients, their treatment is still inadequate, mainly due to the lack data deriving from randomized clinical trials. Factors limiting use standard chemotherapy regimens in are fear toxicity and unexpected side effects. The assessment comorbidity multidimensional geriatric major importance decision plan. All supportive measures must be adopted order successfully treat vulnerable unfit with cancer, particular, growth factors when given curative intent; rule out anemia possible causes anemia, correct them whenever possible; choose cytotoxics according expected adverse events interference concomitant medications. Particular attention paid pain cancer. Caregivers involved plan, phone contacts patient caregivers needed verify physical conditions compliance prescriptions.

参考文章(61)
Anemia in the elderly Hematology. pp. 528- 532 ,(2007) , 10.1007/978-0-387-49506-4
Vito Michele Lauta, Massimo Magagnoli, Luciano Guardigni, Sante Tura, Pier Luigi Zinzani, Monica Bocchia, Brunangelo Falini, Patrizio Mazza, Alfonso Zaccaria, Patrizia Gentilini, Filippo Gherlinzoni, Amalia De Renzo, Sergio Storti, Pier Paolo Fattori, Ettore Volpe, Giuseppe Leone, Francesco Zaja, Maurizio Tabanelli, Luciano Moretti, Enzo Pavone, Maurizio Bendandi, Enrico Aitini, Marco Gobbi, Elderly aggressive-histology non-Hodgkin's lymphoma: First-line VNCOP-B regimen experience on 350 patients Blood. ,vol. 94, pp. 33- 38 ,(1999) , 10.1182/BLOOD.V94.1.33.413K08_33_38
M Wallace, Assessment and management of pain in the elderly. Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses. ,vol. 3, pp. 293- 298 ,(1994)
Lodovico Balducci, Aging, frailty, and chemotherapy. Cancer Control. ,vol. 14, pp. 7- 12 ,(2007) , 10.1177/107327480701400102
Dan L. Longo, Vincent T. DeVita, Susan Molloy Hubbard, The chemotherapy of lymphomas: looking back, moving forward--the Richard and Hinda Rosenthal Foundation award lecture. Cancer Research. ,vol. 47, pp. 5810- 5824 ,(1987)
Martine Extermann, Comprehensive Geriatric Oncology ,(1997)
William E Haley, Family caregivers of elderly patients with cancer: understanding and minimizing the burden of care. The journal of supportive oncology. ,vol. 1, pp. 25- 29 ,(2003)
Blood disorders in the elderly Blood Disorders in the Elderly. pp. 1- 484 ,(2007) , 10.1017/CBO9780511545238
Demetrius Albanes, Total calories, body weight, and tumor incidence in mice. Cancer Research. ,vol. 47, pp. 1987- 1992 ,(1987)