Synthesis of Highly Functionalized Anthraquinones and Evaluation of Their Antitumor Activity
作者： Lutz F. Tietze , Kersten M. Gericke , Ingrid Schuberth
关键词: Human lung 、 In vitro growth 、 Side chain 、 Islandicin 、 Antitumor activity 、 Chemistry 、 Anthraquinones 、 Cycloaddition 、 Mensacarcin 、 Organic chemistry
摘要: Highly functionalized anthraquinones which derive from the natural products mensacarcin, islandicin, and chrysophanol have been efficiently synthesized using a Diels–Alder reaction as key step. The introduction of proposed pharmacophoric side chain unit has achieved by an addition aryllithium species onto different aldehydes. Furthermore, antitumor activity these novel compounds studied in vitro growth inhibition human lung carcinoma cells line A549.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
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