The human selenoproteome: recent insights into functions and regulation
作者： M. A. Reeves , P. R. Hoffmann
DOI: 10.1007/S00018-009-0032-4
关键词: Selenoprotein 、 Selenocysteine 、 Protein family 、 Gene 、 Subcellular localization 、 Amino acid 、 Proteome 、 Isozyme 、 Genetics 、 Biology
摘要: Selenium (Se) is a nutritional trace mineral essential for various aspects of human health that exerts its effects mainly through incorporation into selenoproteins as the amino acid, selenocysteine. Twenty-five selenoprotein genes have been identified in humans and several are broadly classified antioxidant enzymes. As progress made on characterizing individual members this protein family, however, it becoming clear their properties functions quite diverse. This review summarizes recent insights such tissue distribution, subcellular localization, regulation expression. Also discussed potential roles different play disease.
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