Sex differences in T-lymphocyte tissue infiltration and development of angiotensin II hypertension.

摘要: There is extensive evidence that activation of the immune system both necessary and required for development angiotensin II (Ang II)-induced hypertension in males. The purpose this study was to determine whether sex differences exist ability adaptive induce Ang II-dependent central renal T-cell infiltration during II-induced dependent. Recombinant activating gene-1 (Rag-1)(-/-) mice, lacking T B cells, were used. Male female Rag-1(-/-) mice received adoptive transfer male CD3(+) cells 3 weeks before 14-day infusion (490 ng/kg per minute). Blood pressure monitored via tail cuff. In absence systolic blood responses similar between sexes (Δ22.1 mm Hg males versus Δ18 : females). After significantly increased (Δ37.7 Hg; P<0.05) when compared with females (Δ13.7 Hg). Flow cytometric analysis total CD4(+), CD8(+), regulatory Foxp3(+)-CD4(+) subsets identified lymphocyte control II-infused animals (P<0.05). Immunohistochemical staining CD3(+)-positive subfornical organ region brain females. These results suggest are protected from T-cell-mediated increases their counterparts, protection may involve magnitude kidney brain.