Chronic lithium treatment prevents the dexamethasone-induced increase of brain polymine metabolizing enzymes
作者： Gad.M. Gilad , Varda H. Gilad , Richard Jed Wyatt , Robert A. Casero
DOI: 10.1016/0024-3205(92)90289-2
关键词: Lithium chloride 、 Dexamethasone 、 Pharmacology 、 Biology 、 Spermidine 、 Lithium (medication) 、 Endocrinology 、 Internal medicine 、 Spermine 、 Polyamine 、 Ornithine decarboxylase 、 Mechanism of action
摘要: The paper describes the effects of various regimens lithium chloride treatment on dexamethasone-induced increases in brain polyamine metabolizing enzymes. In contrast to peripheral tissues where acute suppresses increase ornithine decarboxylase activity, only chronic was effective preventing this and also activities S-adenosylmethionine spermidine/spermine N1-acetyltransferase. This findings indicate a novel target for lithium's action turn provide new avenues exploring function brain.
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