Differential effect of lithium on spermidine/spermine N1-acetyltransferase expression in suicidal behaviour.

摘要: An altered polyamine system has been suggested to play a key role in mood disorders and suicide, hypothesis corroborated by the evidence that lithium inhibits mediated stress response rat brain. Recent post-mortem studies have shown spermidine/spermine N1-acetyltransferase (SAT1), regulator of cellular content, is under-expressed brains from suicide victims compared controls. In our study we tested effect vitro treatment on SAT1 gene protein expression B lymphoblastoid cell lines (BLCLs) bipolar disorder (BD) patients who committed (and for which BLCLs were collected prior their death), BD with high low riskof sample non-psychiatric Baseline mRNA levels similar four groups subjects (p>0.05). Lithium had no completers (p>0.05) while it significantly increased risk (p<0.001) (p<0.01) as well controls (p<0.001). Protein not correlated; reduced only control (p<0.05). Our findings suggest transcription influenced this completed further supporting polyamines suicide. Received 22 January 2013; Reviewed 2 April Revised Accepted 13 May First published online 17 June 2013