Repositioning of 2,4-Dichlorophenoxy acetic acid as a potential anti-inflammatory agent: In Silico and Pharmaceutical Formulation study

摘要: 2,4-Dichlorophenoxy acetic acid (2,4-D) is a well-known plant auxin which widely used in tissue culture experiments as well weed killer and herbicide. In this study, 2,4-D was rediscovered new anti-inflammatory agent through an silico molecular modeling docking studies along with drug formulation vivo inspection. The indicated high affinity of toward COX-2 enzyme way similar to Ibuprofen, suggesting higher activity. Molecular by both MOE 2013.08 Leadit 2.1.2 revealed excellent binding pattern compared some non-steroidal drugs. formulated different gel bases. vitro release were examine the best formula for studies. carrageenan-induced hind paw edema inflammatory model rats test finding. showed potential activity significantly reduced concentration prostaglandin E2 tissues Ibuprofen. These results may open door introduce molecule; especially that well-investigated regarding its toxicity side effect.