Molecular imaging-guided gene therapy of gliomas.
作者： Maria A. Rueger , Alexandra Winkeler , Anne V. Thomas , Lutz W. Kracht , Andreas H. Jacobs
DOI: 10.1007/978-3-540-77496-9_15
关键词: Magnetic resonance imaging 、 Positron emission tomography 、 Genetic enhancement 、 Immunology 、 Molecular imaging 、 Gene targeting 、 Glioma 、 Medicine 、 Bioinformatics 、 Transduction (genetics) 、 Medical imaging
摘要: Gene therapy of patients with glioblastoma using viral and non-viral vectors, which are applied by direct injection or convection-enhanced delivery (CED), appear to be satisfactorily safe. Up date, only single show a significant therapeutic benefit as deduced from long-term survivors. Non-invasive imaging PET for the identification viable target tissue assessment transduction efficiency shall help identify might gene therapy, while non-invasive follow-up on treatment responses allows early dynamic adaptations options. Therefore, molecular has critical impact development standardised protocols efficient safe vector applications in humans.
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