Presence of a reduced opioid response in interleukin-6 knock out mice.
作者： Mauro Bianchi , Roberto Maggi , Federica Pimpinelli , Tiziana Rubino , Daniela Parolaro
DOI: 10.1046/J.1460-9568.1999.00563.X
关键词: Morphine 、 Receptor 、 Internal medicine 、 Interleukin 6 、 Cytokine 、 Chemistry 、 μ-opioid receptor 、 Endocrinology 、 Hypothalamus 、 Opioid 、 Opioid peptide
摘要: Cytokines are known to influence neuronal functions. The purpose of this study was investigate the putative role cytokine interleukin-6 (IL-6) in pathways involved opioid-mediated responses, by using IL-6-deficient mice. We reported that with a thermal stimulus IL-6-knock-out (IL-6KO) mice presented nociceptive thresholds similar those measured their controls. However, they showed reduced analgesic response both restraint stress and administration low doses morphine. Hypothalamic levels opioid peptide beta-endorphin were significantly higher IL-6KO than development tolerance effect morphine more rapid wild-type Binding experiments number receptors midbrain, but not hypothalamus, decreased Autoradiographic binding analysis revealed density mu diminished while delta-opioid did not. These results suggest IL-6 is necessary for correct mechanisms endogenous exogenous opiates.
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