Preparation, Characterization and Pharmacokinetics Evaluation of the Compound Capsules of Ibuprofen Enteric-Coated Sustained-Release Pellets and Codeine Phosphate Immediate-Release Pellets.

作者: Ling Dong , Feifei Yang , Zhihong Zhu , Yue Yang , Xiaoyu Zhang

DOI: 10.1208/S12249-018-1119-8

关键词: Triethyl citratePlasticizerEthyl celluloseIbuprofenCodeine PhosphateAnalgesicDissolution testingChemistryPelletsChromatography

摘要: … immediate-release and sustained-release pellets to treat the acute and chronic pain. The CP is made into immediate-release pellets … enteric-coated sustained-release pellets (IB-SRPs), …

参考文章(51)
Hong-Xiang Yan, Jin Li, Zheng-Hua Li, Wen-Li Zhang, Jian-Ping Liu, Tanshinone IIA – loaded pellets developed for angina chronotherapy: Deconvolution-based formulation design and optimization, pharmacokinetic and pharmacodynamic evaluation European Journal of Pharmaceutical Sciences. ,vol. 76, pp. 156- 164 ,(2015) , 10.1016/J.EJPS.2015.05.012
João M.S. de Barros, Tabea Lechner, Dimitrios Charalampopoulos, Vitaliy V. Khutoryanskiy, Alexander D. Edwards, Enteric coated spheres produced by extrusion/spheronization provide effective gastric protection and efficient release of live therapeutic bacteria. International Journal of Pharmaceutics. ,vol. 493, pp. 483- 494 ,(2015) , 10.1016/J.IJPHARM.2015.06.051
Mohamed Abbas Ibrahim, Mahmoud El-Badry, Formulation of immediate release pellets containing famotidine solid dispersions Saudi Pharmaceutical Journal. ,vol. 22, pp. 149- 156 ,(2014) , 10.1016/J.JSPS.2013.01.011
MR Abbaspour, F Sadeghi, H Afrasiabi Garekani, Design and study of ibuprofen disintegrating sustained-release tablets comprising coated pellets. European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 68, pp. 747- 759 ,(2008) , 10.1016/J.EJPB.2007.09.010
M.R. Abbaspour, F. Sadeghi, H. Afrasiabi Garekani, Preparation and characterization of ibuprofen pellets based on Eudragit RS PO and RL PO or their combination. International Journal of Pharmaceutics. ,vol. 303, pp. 88- 94 ,(2005) , 10.1016/J.IJPHARM.2005.07.016
F. Podczeck, P.E. Knight, J.M. Newton, The evaluation of modified microcrystalline cellulose for the preparation of pellets with high drug loading by extrusion/spheronization. International Journal of Pharmaceutics. ,vol. 350, pp. 145- 154 ,(2008) , 10.1016/J.IJPHARM.2007.08.040
Aleksandra Dukić-Ott, Jean Paul Remon, Paul Foreman, Chris Vervaet, Immediate release of poorly soluble drugs from starch-based pellets prepared via extrusion/spheronisation. European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 67, pp. 715- 724 ,(2007) , 10.1016/J.EJPB.2007.04.014
Ram Kapil, Arno Nolting, Partha Roy, William Fiske, Irma Benedek, Wattanaporn Abramowitz, Pharmacokinetic properties of combination oxycodone plus racemic ibuprofen: two randomized, open-label, crossover studies in healthy adult volunteers. Clinical Therapeutics. ,vol. 26, pp. 2015- 2025 ,(2004) , 10.1016/J.CLINTHERA.2004.12.013
Xingna Zhao, Guofei Li, Lili Zhang, Xiaoguang Tao, Tingting Guan, Mo Hong, Xing Tang, Preparation and evaluation of nicotinic acid sustained-release pellets combined with immediate release simvastatin. International Journal of Pharmaceutics. ,vol. 400, pp. 42- 48 ,(2010) , 10.1016/J.IJPHARM.2010.08.028