Glioma Through the Looking GLASS: the Glioma Longitudinal Analysis consortium, molecular evolution of diffuse gliomas
作者： Erwin G Van Meir , Roel GW Verhaak , Colin Watts , Pieter Wesseling , Adelheid Woehrer
DOI: 10.1101/196139
关键词: Internal medicine 、 Malignant transformation 、 Epigenomics 、 Disease 、 Glioma 、 Oncology 、 Diffuse Glioma 、 Bioinformatics 、 Phenotype 、 Biology 、 Cancer genome 、 Molecular evolution
摘要: Adult diffuse glioma are a diverse group of intracranial neoplasms associated with disproportional large number productive life years lost, thus imposing highly emotional and significant financial burden on society. Patient death is the result an aggressive course disease following diagnosis. The Cancer Genome Atlas similar projects have provided comprehensive understanding somatic alterations molecular subtypes at However, gliomas undergo evolution during malignant transformation. We review current knowledge genomic, epigenomic transcriptomic abnormalities before after recurrence. outline effort to systemically catalogue longitudinal changes in gliomas, Glioma Longitudinal Analysis Consortium. GLASS initiative will provide essential insights into towards lethal phenotype potential reveal targetable vulnerabilities, ultimately, improved outcomes for patient population need.
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