Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine
作者： William J. Nicklas , Ivy Vyas , Richard E. Heikkila
DOI: 10.1016/0024-3205(85)90146-8
关键词: Neurotoxin 、 MPTP 、 Metabolite 、 Glutamic acid 、 Biology 、 Biochemistry 、 Glutamate receptor 、 Mitochondrion 、 1-Methyl-4-phenylpyridinium 、 NAD+ kinase
摘要: … MPP + may inhibit oxidation of the above substrates at the point of entry of pyridine … The flavin nucleotide-linked reducing equivalents from succinate oxidation would effectively …
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