Quantitative analysis of curcumin-loaded alginate nanocarriers in hydrogels using Raman and attenuated total reflection infrared spectroscopy

摘要: Core-shell nanocarriers are increasingly being adapted in cosmetic and dermatological fields, aiming to provide an increased penetration of the active pharmaceutical or ingredients (API ACI) through skin. In final form, (NC) usually prepared hydrogels, conferring desired viscous properties for topical application. Combined with high chemical complexity encapsulating system itself, involving numerous form a stable core quantifying NC and/or encapsulated without labor-intensive destructive methods remains challenging. this respect, specific molecular fingerprint obtained from vibrational spectroscopy analysis could unambiguously overcome current obstacles development fast cost-effective quality control tools NC-based products. The present study demonstrates feasibility deliver accurate quantification concentrations curcumin (ACI)-loaded alginate hydrogel matrices, coupling partial least square regression (PLSR) infrared (IR) absorption Raman spectroscopic analyses. With respective root mean errors 0.1469 ± 0.0175% w/w 0.4462 ± 0.0631% w/w, both approaches offer acceptable precision. Further investigation PLSR results allowed highlight different selectivity each approach, indicating only IR delivers direct monitoring Labrafac®, main ingredient. analyses rather dominated by contribution ACI which opens perspectives quantify molecules interferences complex core-shell systems thus positioning technique as powerful analytical tool industrial screening