作者: Scott M. Rocklage , Dilip Worah , Sook-Hui Kim
关键词: Gadolinium-Chelate 、 Inorganic chemistry 、 Solubility 、 Gadolinium 、 Selectivity 、 Stereochemistry 、 Chelation 、 Manganese 、 Metal 、 Chemistry 、 In vivo
摘要: At the currently administered clinical doses, paramagnetic metal chelate complexes presently used as MR contrast enhancement agents appear to be relatively nontoxic. Solution thermodynamic, solubility, and selectivity studies, based on a number of gadolinium complexes, indicate that very little is released in vivo, small amounts do remain are available for excretion, albeit slowly. Although mechanism release from manganese-based not well understood, any manganese likely quickly efficiently cleared through liver. MRI unlikely repeatedly patients, which could result accumulation ion, long-term effects such potential deposition have yet demonstrated.