Metal ion release from paramagnetic chelates: what is tolerable?

作者: Scott M. Rocklage , Dilip Worah , Sook-Hui Kim

DOI: 10.1002/MRM.1910220211

关键词: Gadolinium-ChelateInorganic chemistrySolubilityGadoliniumSelectivityStereochemistryChelationManganeseMetalChemistryIn vivo

摘要: At the currently administered clinical doses, paramagnetic metal chelate complexes presently used as MR contrast enhancement agents appear to be relatively nontoxic. Solution thermodynamic, solubility, and selectivity studies, based on a number of gadolinium complexes, indicate that very little is released in vivo, small amounts do remain are available for excretion, albeit slowly. Although mechanism release from manganese-based not well understood, any manganese likely quickly efficiently cleared through liver. MRI unlikely repeatedly patients, which could result accumulation ion, long-term effects such potential deposition have yet demonstrated.

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