Zinc supplementation induces CD4+CD25+Foxp3+ antigen-specific regulatory T cells and suppresses IFN-γ production by upregulation of Foxp3 and KLF-10 and downregulation of IRF-1
作者： Martina Maywald , Lothar Rink
DOI: 10.1007/S00394-016-1228-7
关键词: FOXP3 、 Immune system 、 Zinc 、 Autoimmunity 、 Downregulation and upregulation 、 Immunology 、 Allergy 、 Cell biology 、 Transplant rejection 、 Lymphocyte 、 Biology
摘要: Purpose The essential trace element zinc plays a fundamental role in immune function and regulation since its deficiency is associated with autoimmunity, allergies, transplant rejection. Thus, we investigated the influence of supplementation on Th1-driven alloreaction mixed lymphocyte cultures (MLC), generation antigen-specific T cells, analyzed underlying molecular mechanisms.
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sci-hub.se 参考文章(48)
Detmar Beyersmann, Hajo Haase, Functions of zinc in signaling, proliferation and differentiation of mammalian cells. Biometals. ,vol. 14, pp. 331- 341 ,(2001) , 10.1023/A:1012905406548
John J. O’Shea, Jérôme Galon, Chitra Sudarshan, David Finbloom, Satochi Ito, IL-12 Induces IFN Regulating Factor-1 (IRF-1) Gene Expression in Human NK and T Cells Journal of Immunology. ,vol. 162, pp. 7256- 7262 ,(1999)
Alessandra Fragale, Lucia Gabriele, Emilia Stellacci, Paola Borghi, Edvige Perrotti, Ramona Ilari, Angela Lanciotti, Anna Lisa Remoli, Massimo Venditti, Filippo Belardelli, Angela Battistini, IFN Regulatory Factor-1 Negatively Regulates CD4+CD25+ Regulatory T Cell Differentiation by Repressing Foxp3 Expression Journal of Immunology. ,vol. 181, pp. 1673- 1682 ,(2008) , 10.4049/JIMMUNOL.181.3.1673
Massimo C. Fantini, Christoph Becker, Giovanni Monteleone, Francesco Pallone, Peter R. Galle, Markus F. Neurath, Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. Journal of Immunology. ,vol. 172, pp. 5149- 5153 ,(2004) , 10.4049/JIMMUNOL.172.9.5149
Song Guo Zheng, Ju Hua Wang, William Stohl, Kyoung Soo Kim, J. Dixon Gray, David A. Horwitz, TGF-β Requires CTLA-4 Early after T Cell Activation to Induce FoxP3 and Generate Adaptive CD4+CD25+ Regulatory Cells Journal of Immunology. ,vol. 176, pp. 3321- 3329 ,(2006) , 10.4049/JIMMUNOL.176.6.3321
Nele Wellinghausen, Lothar Rink, The significance of zinc for leukocyte biology. Journal of Leukocyte Biology. ,vol. 64, pp. 571- 577 ,(1998) , 10.1002/JLB.64.5.571
Tatsuya Okamoto, Tamotsu Kuroki, Tomohiko Adachi, Shinichiro Ono, Tomayoshi Hayashi, Yoshitsugu Tajima, Susumu Eguchi, Takashi Kanematsu, Effect of zinc on early graft failure following intraportal islet transplantation in rat recipients. Annals of Transplantation. ,vol. 16, pp. 114- 120 ,(2011) , 10.12659/AOT.882003
C Faber, P Gabriel, K-H Ibs, L Rink, Zinc in pharmacological doses suppresses allogeneic reaction without affecting the antigenic response. Bone Marrow Transplantation. ,vol. 33, pp. 1241- 1246 ,(2004) , 10.1038/SJ.BMT.1704509
Lothar Rink, Cathrin A. Campo, Nele Wellinghausen, Christian Faber, Andrea Fischer, Zinc inhibits the mixed lymphocyte culture. Biological Trace Element Research. ,vol. 79, pp. 15- 22 ,(2001) , 10.1385/BTER:79:1:15
Jennifer Kaltenberg, Laura M. Plum, Julia L. Ober‐Blöbaum, Andrea Hönscheid, Lothar Rink, Hajo Haase, Zinc signals promote IL‐2‐dependent proliferation of T cells European Journal of Immunology. ,vol. 40, pp. 1496- 1503 ,(2010) , 10.1002/EJI.200939574