GATA3 Is a Sensitive and Specific Marker of Benign and Malignant Mesonephric Lesions in the Lower Female Genital Tract

摘要: GATA3 is a transcription factor critical for embryogenesis, development, and cell differentiation. Recent studies have suggested that sensitive relatively specific biomarker urothelial breast carcinomas, with most Mullerian carcinomas being negative. We investigated expression in mesonephric/Wolffian remnants tumors the female genital tract. A western blot was performed to assess specificity antibody. immunohistochemistry on 59 formalin-fixed paraffin-embedded mesonephric samples, including 17 (MR; 11 cervical 6 fallopian tube), 15 hyperplasias, 21 adnexal of probable Wolffian origin. Thirty conventional endocervical adenocarcinomas (ENDO-CA), 9 gastric-type adenocarcinomas, 165 endometrial (EM-CA) were also evaluated. nuclear intensity extent staining The revealed seminal vesicle lines derived from but not other ovarian, cervical, cancers. All MRs 5/6 (83%) tube MRs, 20/21 (95%) positive, although great variability both (weak strong) (1+ 3+) staining. Only 1/6 (17%) origin showed weak multifocal One 30 (3%) usual-type ENDO-CAs 3/165 EM-CAs exhibited weak-moderate immunoreactivity; all highly marker lesions lower tract; however, its utility upper tract may be more limited. In addition, can aid distinguishing uterine EM-CAs.