Molecular Basis for Abnormal Parturition in Zinc Deficiency in Rats

摘要: Apgar (1968a) was the first to recognize that female rats fed a diet containing 1 μg Zn/g throughout gestation experienced difficult and prolonged labor accompanied by excessive bleeding. Placentae were left unconsumed neonates abandoned rather than cleaned nursed. Further studies (1968b, 1970, 1972, 1973, 1975, 1976, 1977a,b) showed such effects relatively specific for zinc since they did not appear in restricted-fed or diets low protein, thiamine, copper manganese. Moreover, observed typical syndrome still developed when low-zinc begun as late day 18 of could be prevented repletion instituted on 19 offered from mating. O’Dell et al., (1977) reported zinc-deficient dams also exhibited significant decrease body temperature (38.3° vs 36.9° C), hypotension (115 90 mm Hg) delayed, well prolonged, parturition. Others have toxic during pregnancy high content phytate, substance known bind make it unavailable absorption (Eklund, 1973; McLaughlan 1975; Anderson 1976). During course our laboratory 1977 effect nutrition lens development, we employed mineral mix contained only 3–5 diet, an amount expected sufficient. Upon observing described above, became aware this unique decided attempt determine its molecular basis.