The distribution of native albumin and foreign albumin injected into lateral ventricles of prenatal and neonatal rat forebrains.

摘要: Several plasma proteins are found within the cells of developing brain many species, with a distribution pattern which changes during development, but origin such is in dispute. The experiments described here were designed to test hypothesis that some able take up proteins. protein albumin has been studied rat forebrain from 14th day gestation until birth. Although present cerebrospinal fluid and earliest age studied, was not seen 16E or 17E. A foreign protein, sheep albumin, injected into ventricles at days 14E, 16E, 18E, 20E on Sheep can be detected presence because antibody does cross-react albumin. taken very rapidly ventricular zone later earlier ages, thus mimicking naturally occurring After had left ventricle for several hours, cortical plate also contained again normal These findings suggest largely attributed uptake rather than synthesis.