Coeliac disease and risk of mood disorders--a general population-based cohort study.

作者: Jonas F. Ludvigsson , Johan Reutfors , Urban Ösby , Anders Ekbom , Scott M. Montgomery

DOI: 10.1016/J.JAD.2006.08.032

关键词: ComorbidityCohort studyBipolar disorderDepression (differential diagnoses)Risk factorMood disordersInternal medicinePsychiatryOdds ratioPopulationMedicine

摘要: Abstract Background Earlier research has indicated a positive association between coeliac disease (CD) and some mental disorders. Studies on CD depression have inconsistent findings we know of no study the risk bipolar disorder (BD). Methods We used Cox regression to investigate subsequent mood disorders (MD); BD in 13,776 individuals with 66,815 age- sex-matched reference general population-based cohort Sweden. also studied prior MD through conditional logistic regression. Results was associated an increased (Hazard ratio (HR) = 1.8; 95% CI = 1.6–2.2; p  = 0.779, based 22 99 events). Individuals (OR = 2.3; CI = 2.0–2.8;  = 0.001) were at diagnosis CD. Limitations Study participants may more severe than average patient these since they identified hospital-based register. Conclusions is positively depression. The increase for be due screening among those MD.

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