Rapid Turnover of T Lymphocytes in SIV-Infected Rhesus Macaques
作者： Hiroshi Mohri , Sebastian Bonhoeffer , Simon Monard , Alan S Perelson , David D Ho
DOI: 10.1126/SCIENCE.279.5354.1223
关键词: Virus 、 Cell killing 、 Natural killer cell 、 Virology 、 Biology 、 Lymphocyte 、 Immunology 、 CD8 、 Simian immunodeficiency virus 、 Lentivirus 、 T lymphocyte 、 Multidisciplinary
摘要: Studies of lymphocyte turnover in animal models have implications for understanding the mechanism cell killing and extent regeneration human immunodeficiency virus infection. Quantitative analyses sequential changes bromodeoxyuridine labeling CD4 CD8 T lymphocytes not only revealed normal proliferation death rates these populations uninfected macaques, but also showed a substantial increase associated with simian (SIV) Faster delabeling memory naive subpopulations as well NK (natural killer) B cells were observed infected suggesting state generalized activation induced by SIV.
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