Evaluation of wound healing potential of β-chitin hydrogel/nano zinc oxide composite bandage
作者： Sudheesh Kumar PT , Vinoth-Kumar Lakshmanan , Mincy Raj , Raja Biswas , Tamura Hiroshi
DOI: 10.1007/S11095-012-0898-Y
关键词: Wound healing 、 Freeze-drying 、 Platelet activation 、 Bandage 、 Nuclear chemistry 、 Surgery 、 Distilled water 、 Chemistry 、 Composite number 、 Chitin 、 Swelling
摘要: β-chitin hydrogel/nZnO composite bandage was fabricated and evaluated in detail as an alternative to existing bandages. hydrogel synthesized by dissolving powder Methanol/CaCl2 solvent, followed the addition of distilled water. ZnO nanoparticles were added stirred for homogenized distribution. The resultant slurry frozen at 0°C 12 h. samples lyophilized 24 h obtain porous bandages showed controlled swelling degradation. blood clotting ability well platelet activation, which higher when compared control. antibacterial activity proven against Staphylococcus aureus (S. aureus) Escherichia coli (E.coli). Cytocompatibility assessed using human dermal fibroblast cells (HDF) these on viable similar Kaltostat control bare based viability reduced 50–60% with concentration zinc oxide (nZnO) 80–90% lower nZnO. In vivo evaluation Sprague Dawley rats (S.D. rats) faster healing collagen deposition prepared can be used various types infected wounds large volume exudates.
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