MicroRNAs as therapeutic targets and their potential applications in cancer therapy.
作者： William CS Cho
DOI: 10.1517/14728222.2012.696102
关键词: microRNA 、 Suppressor 、 Oncogene 、 Bioinformatics 、 Carcinogenesis 、 Tumor suppressor gene 、 Cancer 、 Biology 、 Cancer therapy 、 Oncomir 、 Computational biology
摘要: Introduction: The results of cancer-associated miRNA research have yielded surprising insights into the pathogenesis a range different cancers. Many dysregulated miRNAs are involved in regulation genes that essential for carcinogenesis. Areas covered: This review discusses latest discovery acting as oncogenes and tumor suppressor genes, well potential applications regulations cancer therapy. Several translational studies demonstrated feasibility targeting oncogenic restoring tumor-suppressive therapy using vivo model systems. Expert opinion: extensive regulators progression. With increasing understanding target cellular behaviors influenced by them, modulating activities may provide exciting opportunities Despite hurdles incurred acquiring effective systemic drug delivery systems, therapeu...
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