One or two genetic loci mediate high opiate analgesia in selectively bred mice.

摘要: The analgesic responses of humans and laboratory animals are characterized by substantial individual differences. genetic basis this variability can be studied experimentally in rodents using a program selective breeding. One such selected for high (HA) low (LA) swim stress-induced analgesia (SSIA) on the hot-plate (56 degrees C) test Swiss-Webster mice. These lines, which have been selectively bred more than 25 generations, display markedly divergent opioid-mediated SSIA (3-min swims 38 C water), morphine (10 mg/kg, i.p.), to kappa-receptor agonist, U-50,488H (30 i.p.). present study investigated mode inheritance these opioid analgesias HA LA mice, Mendelian analyses. We report that differential sensitivity mice each manipulations appears determined oligogenically, one or at most two major loci. loci associated with type do not co-segregate, however, indicating three distinct oligogenic effects identified. findings suggest determination mechanisms may simple components as amenable further analysis molecular techniques.