CpG island methylation of microRNAs is associated with tumor size and recurrence of non-small-cell lung cancer
作者： Kentaro Kitano , Kousuke Watanabe , Noriko Emoto , Hidenori Kage , Emi Hamano
DOI: 10.1111/J.1349-7006.2011.02101.X
关键词: DNA methylation 、 Combined bisulfite restriction analysis 、 Carcinoma 、 Bioinformatics 、 Tumor progression 、 Lung cancer 、 CpG site 、 Methylation 、 microRNA 、 Biology 、 Cancer research
摘要: We investigated whether the CpG island methylation of certain microRNAs was associated with clinicopathological features and prognosis non-small-cell lung cancer. The mir-152, -9-3, -124-1, -124-2, -124-3 analyzed in 96 cancer specimens using a combined bisulfite restriction analysis. median observation period 49.5 months. mir-9-3, individually an advanced T factor independent age, sex, smoking habit. Moreover, multiple microRNA loci poorer progression-free survival univariate Our result enlightens accumulation aberrant DNA which occurs concordance tumor progression.
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