Fungal infection models: Current progress of ex vivo methods.

摘要: Experimental alternative ex vivo models that simulate infectious processes in are of fundamental importance for the evaluation new drugs, since some cases, their execution does not depend on approval an ethics committee research. Although studies using to evaluate efficacy antifungal molecules have been increasingly described and reported, there is no critical consensus establishes most appropriate ones regarding type infection. Numerous contemplate protocols fungal infections nails, corneas, dentinal tubules skin reveal counterpoints concordances yet finely confronted. In this minireview, we propose a analysis main candidates both topical systemic use, as opposed advantages disadvantages traditional employed preclinical