Expression profiles of relaxin family peptides and their receptors indicate their influence on spermatogenesis in the domestic cat (Felis catus)

摘要: Disturbed spermatogenesis is a common problem in felines. Studying the domestic cat can improve understanding of biological background and help to counteract fertility problems other feline species. Here, we analyzed 3 relaxin family peptides (relaxin, relaxin-3, INSL3) their receptors (RXFP1, RXFP2, RXFP3) as potential spermatogenic factors involving expression testis at different stages its development. It may be concluded from stage-dependent that relaxin, together with RXFP1, appears involved first stage spermatogenesis, whereas relaxin-3 via binding RXFP3 influences spermiogenesis. Furthermore, correlations were observed between RXFP2 messenger RNA expression, relative numbers haploid cells testes. The peptide INSL3 was highly expressed all development stages. Because low stage-independent receptor an auto- and/or paracrine function seems unlikely. In adult testis, predominantly occurs tubular compartment, INLS3 mainly interstitium.