Molecular mechanisms of lymphatic vascular development.
作者： T. Mäkinen , C. Norrmén , T. V. Petrova
DOI: 10.1007/S00018-007-7040-Z
关键词: Inflammation 、 Cancer research 、 Lymphangiogenesis 、 Pathology 、 Zebrafish 、 Model organism 、 Lymphatic system 、 Podoplanin 、 Lymphedema 、 Biology 、 Metastasis
摘要: Lymphatic vasculature has recently emerged as a prominent area in biomedical research because of its essential role the maintenance normal fluid homeostasis and involvement pathogenesis several human diseases, such solid tumor metastasis, inflammation lymphedema. Identification lymphatic endothelial specific markers regulators, VEGFR-3, VEGF-C/D, PROX1, podoplanin, LYVE-1, ephrinB2 FOXC2, development mouse models have laid foundation for our understanding major steps controlling growth remodeling vessels. In this review we summarize recent advances field discuss how knowledge well use model organisms, zebrafish Xenopus, should allow further depth analysis vascular system.
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sci-hub.se 参考文章(123)
M. C. Puri, J. Rossant, K. Alitalo, A. Bernstein, J. Partanen, THE RECEPTOR TYROSINE KINASE TIE IS REQUIRED FOR INTEGRITY AND SURVIVAL OF VASCULAR ENDOTHELIAL-CELLS The EMBO Journal. ,vol. 14, pp. 5884- 5891 ,(1995) , 10.1002/J.1460-2075.1995.TB00276.X
Beatriz Sosa-Pineda, Jeffrey T. Wigle, Guillermo Oliver, Hepatocyte migration during liver development requires Prox1 Nature Genetics. ,vol. 25, pp. 254- 255 ,(2000) , 10.1038/76996
V. Joukov, K. Pajusola, A. Kaipainen, D. Chilov, I. Lahtinen, E. Kukk, O. Saksela, N. Kalkkinen, K. Alitalo, A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. The EMBO Journal. ,vol. 15, pp. 290- 298 ,(1996) , 10.1002/J.1460-2075.1996.TB00359.X
Silvana Breiteneder-Geleff, Afschin Soleiman, Heinrich Kowalski, Reinhard Horvat, Gabriele Amann, Ernst Kriehuber, Katja Diem, Wolfgang Weninger, Erwin Tschachler, Kari Alitalo, Dontscho Kerjaschki, Angiosarcomas Express Mixed Endothelial Phenotypes of Blood and Lymphatic Capillaries: Podoplanin as a Specific Marker for Lymphatic Endothelium American Journal of Pathology. ,vol. 154, pp. 385- 394 ,(1999) , 10.1016/S0002-9440(10)65285-6
Taija Mäkinen, Lotta Jussila, Tanja Veikkola, Terhi Karpanen, Mikko I. Kettunen, Kalevi J. Pulkkanen, Risto Kauppinen, David G. Jackson, Hajime Kubo, Shin-Ichi Nishikawa, Seppo Ylä-Herttuala, Kari Alitalo, Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3 Nature Medicine. ,vol. 7, pp. 199- 205 ,(2001) , 10.1038/84651
Amparo Palmer, Manuel Zimmer, Kai S Erdmann, Volker Eulenburg, Annika Porthin, Rolf Heumann, Urban Deutsch, Rüdiger Klein, EphrinB Phosphorylation and Reverse Signaling Molecular Cell. ,vol. 9, pp. 725- 737 ,(2002) , 10.1016/S1097-2765(02)00488-4
Jeffrey T. Wigle, Kamal Chowdhury, Peter Gruss, Guillermo Oliver, Prox1 function is crucial for mouse lens-fibre elongation. Nature Genetics. ,vol. 21, pp. 318- 322 ,(1999) , 10.1038/6844
Mahir A.A. Al-Rawi, Wen G. Jiang, Gareth Watkins, Robert E. Mansel, The effects of interleukin-7 on the lymphangiogenic properties of human endothelial cells International Journal of Oncology. ,vol. 27, pp. 721- 730 ,(2005) , 10.3892/IJO.27.3.721
Janet Rossant, Juha Partanen, Alan Bernstein, Mira C. Puri, Interaction of the TEK and TIE receptor tyrosine kinases during cardiovascular development Development. ,vol. 126, pp. 4569- 4580 ,(1999)
R. Bell, G. Brice, A. Child, V. Murday, S. Mansour, C. Sandy, J. Collin, A. Brady, D. Callen, K. Burnand, P. Mortimer, S. Jeffery, Analysis of lymphoedema-distichiasis families for FOXC2 mutations reveals small insertions and deletions throughout the gene Human Genetics. ,vol. 108, pp. 546- 551 ,(2001) , 10.1007/S004390100528