Co-evolution of transcriptional and post-translational cell-cycle regulation

摘要: DNA microarray studies have shown that hundreds of genes are transcribed periodically during the mitotic cell cycle humans, budding yeast, fission yeast and plant Arabidopsis thaliana. Here we show despite fact protein complexes involved in this process largely same among all eukaryotes, their regulation has evolved considerably. Our comparative analysis several large-scale data sets reveals although regulated subunits each complex expressed just before its time action, identity proteins differs significantly between organisms. Moreover, these changes transcriptional co-evolved with post-translational control independently lineages; loss or gain cell-cycle-regulated transcription specific is often mirrored by phosphorylation they encode. results indicate many different solutions for assembling molecular machines at right cycle, involving both layers jointly dynamics biological systems.