Regulation of mammalian sperm capacitation by endogenous molecules

摘要: Regulation of mammalian sperm capacitation by endogenous molecules Capacitation in vitro spermatozoa can be regulated a number first messengers, including fertilization promoting peptide, adenosine, calcitonin and angiotensin II, all which are found seminal plasma. The responses appear to involve several separate signal transduction pathways that have common end point. These seminal-plasma derived messengers bind specific receptors directly or indirectly modulate the activity membrane-associated adenylyl cyclase isoforms production second messenger cAMP. Responses these except II initial acceleration cAMP followed inhibition both spontaneous acrosome loss, resulting maintenance fertilizing potential. Appropriate G proteins various phosphodiesterase also involved. transition from stimulatory inhibitory involves loss decapacitation factors (DF) (DF-R) on external surface; DF-R present mouse human has recently been identified as phosphatidylethanolamine-binding protein 1. presence/ absence DF appears cause changes plasma membrane then alter functionality proteins, receptors. Since contact at ejaculation, it is plausible their actions observed occur vivo, allowing play pivotal role enhancing chances successful fertilization.