Long-Term Bone Marrow Culture in Autologous Transplantation: An In Vitro Biological System for Purging Leukemic Cells
作者： L. H. Coutinho , A. Will , J. Chang , N. G. Testa , T. M. Dexter
DOI: 10.1007/978-1-4612-3762-4_17
关键词: Medicine 、 Alternative strategy 、 Internal medicine 、 Autologous bone 、 Human leukocyte antigen 、 Disease 、 Autologous transplantation 、 In vitro 、 Bone marrow culture 、 Oncology 、 Autogenous bone
摘要: Allogeneic bone marrow transplantation is now commonly used as the treatment of choice for patients with leukaemia. However, relatively low number (about 30%) suitable HLA compatible donors and serious complications associated graft-versus-host disease (GVHD) are important factors which limit therapeutic application this procedure. In order to widen range who could benefit from highly aggressive regimens, autologous being increasingly explored an alternative strategy.
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