Epidermal growth factor receptors in the oesophagus.
作者： J Jankowski , S Murphy , G Coghill , A Grant , K G Wormsley
DOI: 10.1136/GUT.33.4.439
关键词: Esophageal disease 、 Biopsy 、 Esophagitis 、 Staining 、 Basal (phylogenetics) 、 Gastroenterology 、 Epidermal growth factor 、 Pathology 、 Biology 、 Esophagus 、 Internal medicine 、 Epithelium
摘要: The quantity and distribution of epidermal growth factor receptors (EGF-R) in oesophageal mucosa was studied the oesophagus order to determine its role disease. Fifty five biopsies were taken from different levels 25 consecutive patients undergoing endoscopy. Another group eight with histologically proven Barrett's oesophagitis had a biopsy area columnar lined oesophagus. A peripheral, membranous pattern seen predominantly confined basal immediately suprabasal cells all first patients. In superficial few granular cytoplasmic structures positive. All showed EGF-R staining surface epithelium. computerised planimeter used proportion stained areas squamous which expressed as percentage total cells. difference for between normal inflamed (29.5% 43.1% respectively) significant (p less than 0.001).
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sci-hub.se 参考文章(47)
Todderud G, Carpenter G, Epidermal growth factor: the receptor and its function. Biofactors. ,vol. 2, pp. 11- ,(1989)
A. Leutz, T. Graf, Relationships Between Oncogenes and Growth Control Peptide Growth Factors and Their Receptors II. pp. 655- 703 ,(1990) , 10.1007/978-3-642-74781-6_22
D. C. Lee, K. M. Han, Expression of Growth Factors and Their Receptors in Development Peptide Growth Factors and Their Receptors II. pp. 611- 654 ,(1990) , 10.1007/978-3-642-74781-6_21
S A Buhrow, S Cohen, J V Staros, Affinity labeling of the protein kinase associated with the epidermal growth factor receptor in membrane vesicles from A431 cells. Journal of Biological Chemistry. ,vol. 257, pp. 4019- 4022 ,(1982) , 10.1016/S0021-9258(18)34676-3
P J Parker, S Young, W J Gullick, E L Mayes, P Bennett, M D Waterfield, Monoclonal antibodies against the human epidermal growth factor receptor from A431 cells. Isolation, characterization, and use in the purification of active epidermal growth factor receptor. Journal of Biological Chemistry. ,vol. 259, pp. 9906- 9912 ,(1984) , 10.1016/S0021-9258(17)42785-2
Lloyd E King, Ronald E Gates, Christa M Stoscheck, Lillian B Nanney, The EGF/TGFα Receptor in Skin Journal of Investigative Dermatology. ,vol. 94, pp. s164- s170 ,(1990) , 10.1111/1523-1747.EP12876141
J.-C. Reubi, H. Portengen, A. M. A. C. Trapman, J. Alexieva-Figusch, W. L. J. Van Putten, J. A. Foekens, J. G. M. Klijn, Prognostic Value of Receptors for Insulin-like Growth Factor 1, Somatostatin, and Epidermal Growth Factor in Human Breast Cancer Cancer Research. ,vol. 49, pp. 7002- 7009 ,(1989)
Ulrich Rodeck, Meenhard Herlyn, Manjusri Das, Uma Murthy, Aruna Basu, Laura Mattes, Presence of Tumor-associated Antigens in Epidermal Growth Factor Receptors from Different Human Carcinomas Cancer Research. ,vol. 47, pp. 2531- 2536 ,(1987)
Edward M. Messing, Clinical implications of the expression of epidermal growth factor receptors in human transitional cell carcinoma. Cancer Research. ,vol. 50, pp. 2530- 2537 ,(1990)
D G Wu, L H Wang, G H Sato, K A West, W R Harris, J W Crabb, J D Sato, Human epidermal growth factor (EGF) receptor sequence recognized by EGF competitive monoclonal antibodies. Evidence for the localization of the EGF-binding site. Journal of Biological Chemistry. ,vol. 264, pp. 17469- 17475 ,(1989) , 10.1016/S0021-9258(18)71518-4