Assessing phytoestrogen exposure in epidemiologic studies: development of a database (United States).

摘要: Background and objective: Phytoestrogens (weak estrogens found in plants or derived from plant precursors by human metabolism) have been hypothesized to reduce the risk of a number cancers. However, epidemiologic studies addressing this issue are hampered lack comprehensive phytoestrogen database for quantifying exposure. The purpose research was develop such use with food-frequency questionnaires large studies. Methods: is based on consumption patterns semistructured interviews 118 African-American, Latina, white women residing California's San Francisco Bay Area. HPLC-mass spectrometry used determine content seven specific phytoestrogenic compounds (i.e. isoflavones: genistein, daidzein, biochanin A, formononetin; coumestan: coumestrol; lignans: matairesinol secoisolariciresinol) each 112 food items/groups. Results: Traditional soy-based foods were contain high levels genistein as expected, well substantial amounts coumestrol. A wide variety "hidden" sources soy (that is, protein isolate, concentrate, flour added foods) observed. Several other (such various types sprouts dried fruits, garbanzo beans, asparagus, garlic, licorice) also be contributors one more phytoestrogens analyzed. Conclusions: Databases, described here, important assessing relationship between exposure cancer Agencies, United States Department Agriculture (USDA), that routinely provide data composition, which investigations into dietary health effects based, should consider instituting programs analysis phytochemicals, including phytoestrogens.