In vitro efficacy of shampoos containing miconazole, ketoconazole, climbazole or accelerated hydrogen peroxide against Microsporum canis and Trichophyton species

摘要: Objectives The objective was to evaluate the antifungal efficacy of shampoo formulations ketoconazole, miconazole or climbazole and accelerated hydrogen peroxide wash/rinse against Microsporum canis Trichophyton species spores. Methods Lime sulfur (1:16)-treated control, enilconazole (1:100)-treated (AHP 7%) 1:20 a 1:10 dilution 2%, 2%/chlorhexidine gluconate 2-2.3%, ketoconazole 1%/chlorhexidine 0.5%/chlorhexidine 3% sterile water-untreated control were tested in three experiments. In first, suspension infective spores hair/scale fragments incubated with 1:10, 1:5 1:1 test solutions for 10 mins. second, toothbrushes containing infected cat hair bristles soaked agitated mins, rinsed, dried then fungal cultured (n = 12×). third, 3 min contact time combined an AHP rinse 10×). Good defined as no growth. Results Water controls grew >300 colony-forming units/plate all culture-positive prior testing. For tests, products showed good efficacy. Miconazole 1% after time. achieved shorter (3 mins) only if rinse. Conclusions relevance continued show countries situations where these cannot be used, shampoos are alternative haircoat disinfectants, mins