Liquid-based cytology in fine-needle aspiration of breast lesions: a review.

摘要: Objective: Fine-needle aspiration (FNA) is a safe and cost-effective technique for the diagnosis of breast lesions, especially when correlated with clinical imaging studies. However, success FNA highly dependent on adequate preparation cytological conventional smears (CS). The liquid-based cytology (LBC) consists an automated method preparing thin-layer samples from cell suspensions collected in alcohol-based preservative. LBC designed to improve CS by avoiding limiting factors such as obscuring material, air-drying smearing artifacts. Study Design: We performed review published literature about applied FNA. Results: preparations aspirates demonstrated better cellular preservation, less overlapping elimination blood excessive inflammation compared CS. Conversely, alterations architecture morphology well loss myoepithelial cells stromal elements have been described specimens, requiring training before applying this diagnosis. Studies shown similar accuracy between lesions. also permits use residual material ancillary tests, which important advantage Conclusions: can be safely FNA, showing diagnostic