作者: Keith L. Black , Nagendra S. Ningaraj
DOI: 10.1177/107327480401100304
关键词: Convection-Enhanced Delivery 、 Permeability (electromagnetism) 、 Nanoparticles for drug delivery to the brain 、 Capillary endothelial cells 、 Cellular mechanism 、 Medicine 、 Pathology 、 Drug delivery 、 Brain tumor 、 Cancer research 、 Vesicle
摘要: Background The blood-brain tumor barrier (BTB) significantly impedes delivery of most hydrophilic molecules to brain tumors. Several promising strategies, however, have been developed overcome this problem. Methods We discuss several drug methods tumor, including intracerebroventricular, convection enhanced delivery, BBB/BTB disruption, and BTB permeability modulation, which was in our laboratory. Results Using immunolocalization, immunoblotting, potentiometric studies, we found that capillary endothelial cells overexpress certain unique protein markers are absent or barely detectable normal cells. biochemically modulated these sustain enhance varying sizes, selectively tumors rat syngeneic xenograft models. also demonstrated the cellular mechanism for vasomodulator-mediated increase is due accelerated formation pinocytotic vesicles transport therapeutic across BTB. Conclusions Other deliver drugs effective but severe drawbacks. Our strategy targets BTB-specific proteins antineoplastic with few no side effects, thus increasing possibility improving treatment.