Long-term effects of growth hormone therapy on patients with Prader-Willi syndrome.
作者： Ilkka Sipilä , Harri Sintonen , Heikki Hietanen , Marjo Apajasalo , Soili Alanne
DOI: 10.1111/J.1651-2227.2010.01904.X
关键词: Hormone therapy 、 Growth hormone 、 Young adult 、 Growth hormone treatment 、 Adult height 、 Medicine 、 Quality of life 、 Cumulative dose 、 Endocrinology 、 Hormone 、 Internal medicine
摘要: Aim: To assess the effects of recombinant human growth hormone (rhGH) treatment in children with Prader–Willi syndrome. Design: A 1-year study and an observational follow-up visit 10 years later. Methods: In 20 patients syndrome (PWS): clinical assessment, laboratory tests, body composition analysis by dual energy X-ray absorptiometry, sleep polygraphy, health-related quality life assessed 16D. Results: Only two had normal secretion at baseline. All were significantly shorter than their expected heights, but experienced catch-up during treatment. At follow-up, 13 reached adult heights markedly taller historical controls. The cumulative dose rhGH over correlated inversely total fat percentage (p = 0.033). However, remained severely obese 10 years. Sleep polygraphy was abnormal more half patients. Health-related substantially below that population. Conclusion: Growth improved height subjects PWS when compared to data. reduction fat; nevertheless, obese.
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