Growth hormone therapy for children and adolescents with Prader-Willi syndrome is associated with improved body composition and metabolic status in adulthood.
作者： Muriel Coupaye , Françoise Lorenzini , Célia Lloret-Linares , Catherine Molinas , Graziella Pinto
DOI: 10.1210/JC.2012-2881
关键词: Fat mass 、 Internal medicine 、 Gh treatment 、 Pediatrics 、 Endocrinology 、 Genetic diagnosis 、 Hormone replacement therapy (female-to-male) 、 Context (language use) 、 Growth hormone 、 Medicine 、 Body mass index 、 Mean age
摘要: Context: Children with Prader-Willi syndrome (PWS) who receive GH treatment have improved growth and body composition; however, data are lacking for adults when is discontinued after completion of growth. Objectives: Our aim was to compare composition metabolic status in PWS according childhood adolescence. Design: 64 (mean age: 25.4 years) a genetic diagnosis were evaluated: 20 received (T), which had been at the time this study, 44 did not (C). Mean duration T group 4.4 ± 2.7 years, age baseline 11.8 mean between end current evaluation 7.0 years. Main Outcomes Measures: Dual-energy X-ray absorptiometry used assess fasting biological analyses evaluated status. Results SD): Body mass index percentage fat significantly lower (32....
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