Eight Years of Growth Hormone Treatment in Children With Prader-Willi Syndrome: Maintaining the Positive Effects
作者： N. E. Bakker , R. J. Kuppens , E. P. C. Siemensma , R. F. A. Tummers-de Lind van Wijngaarden , D. A. M. Festen
DOI: 10.1210/JC.2013-2012
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摘要: Background: The most important reason for treating children with Prader-Willi syndrome (PWS) GH is to optimize their body composition. Objectives: aim of this ongoing study was determine whether long-term treatment can counteract the clinical course increasing obesity in PWS by maintaining improved composition brought during early treatment. Setting: This a multicenter prospective cohort study. Methods: We have been following 60 prepubertal 8 years continuous (1 mg/m2/d ≅ 0.035 mg/kg/d) and used same dual-energy x-ray absorptiometry machine annual measurements lean mass percent fat. Results: After significant increase first year (P < .0001), remained stable 7 at level above baseline .0001). decrease year, fat SD score (SDS) index SDS not significantly higher than = .06, P...
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